贺天珍

发布者:赵林霞发布时间:2019-09-01动态浏览次数:633


贺天珍,南通大学特种医学研究院副研究员。澳门大学生物医药学博士,曾访学于美国国立卫生研究院NIH/NCI


研究方向:免疫细胞参与内脏痛的调控及机制


主持的科研项目:

1. 国家自然科学青年基金,Trip13-HAT1信号轴调控炎症性肠病肠黏膜Treg细胞增殖的机制研究,2021年,30万,主持

2. 南通市科技项目,长链非编码RNA656抑制UBE4A介导的HAT1泛素化调控大肠癌微环境中Treg细胞增殖的机制研究,2021年,5万,主持


代表性SCI论文:

1. Tianzhen He, De Yang, Xiao-Qing Li, Mengmeng Jiang, Md Sahidul Islam, Shaokui Chen, Yibo Chen, Yang Yang, Chon-kit Chou, Anna Trivett, Joost J. Oppenheim, and Xin Chen. Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells. Science Advances, 2020, 6 (40): eaba6584 (Nature Index 期刊IF: 13.116)

2. He T, Liu S, Chen S, Ye J, Wu X, Bian Z and Chen X (2018) The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells. Front. Immunol. 9:1556. doi: 10.3389/fimmu.2018.01556 (IF: 5.511)

3. Huimin Zou, Tianzhen He, Xin Chen. Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells. International Immunopharmacology. 2019: 69: 307-312. (IF: 3.118)

4. Keqiang Chen, Vijay K Singh, Peng Tang, Zhiyao Bao, Tianzhen He, Yi Xiang, Wanghua Gong, Teizo Yoshimura, Yingying Le, Lino Tessarollo, Xin Chen and Ji Ming Wang (2018). Deficiency in Fpr2 results in reduced number of Lin-c-Kit+Sca1+ myeloid progenitor cells. J. Biol. Chem. doi: 10.1074/jbc.RA118.002683 (IF: 4.010)


会议论文:

1. Tianzhen He, De Yang, Xin Chen and Joost J. Oppenheim. Tetrandrine (TET) upregulated mTNF expression on dendritic cells and consequently induces TNFR2 mediated proliferation of Tregs. J Immunol. 2018, 200 (1 Supplement) 47.19

2. Xin Chen and Tianzhen He. The p38 MAPK inhibitor SB203580 abrogated TNF-mediated expansion of regulatory T cells (Abstract). Journal of immunology, J Immunol. 2017, 198 (1 Supplement) 141.16


专利:

1. 张雨青、周丽霞、马永雷、卢立真、周珍祯、李琳、贺天珍、阎海波,一种蚕茧丝胶层醇溶物及其制备方法,发明专利,申请号:200910027117.8,申请日:2009-5-22;公开号:CN101601640A, 2009-12-16公开

2. 张雨青、卢立真、马永雷、周丽霞、贺天珍、周珍祯、李  琳,一种从紫甘薯中提取花色苷的方法,发明专利,申请号: 200910234497.2, 2009.11.20; 公开号:CN101735644A, 2010-6-16公开