高永静,神经生物学专业博士,博士生导师,教授,疼痛医学研究院/特种医学研究院副院长,江苏特聘教授。1995年毕业于南通医学院临床医学专业,1999年获南通医学院人体解剖学硕士学位,2004年获得复旦大学神经生物学博士学位。2006-2010年先后在美国圣路易斯华盛顿大学医学院和美国哈佛大学医学院留学。从事慢性疼痛的神经机制研究20余年,在SCI收录的期刊上发表论文60多篇,包括Journal of Clinical Investigation, Journal of ExperimentalMedicine,Nature Communication, PNAS, Journal of Neuroscience等国际权威期刊。发表的论文受到国际国内同行广泛引用,2014-2018年连续5年入选Elsevier中国被高引学者榜“神经科学”专业榜单。近年来主持多项国家自然科学基金、江苏省自然科学基金。先后入选教育部新世纪优秀人才支持计划、江苏省“333”工程第三层次人才、南通市“226”工程第二层次人才、江苏特聘教授;获得南通市青年科技奖,南通市优秀科技工作者等。目前担任《Brain Research Bulletin》,《NeuroscienceBulletin》、《中国疼痛医学杂志》编委,中华医学会疼痛学分会基础组委员会副组长、中国神经科学学会胶质细胞分会秘书长、江苏省医学会疼痛学分会委员等职务,担任国家自然科学基金项目青年基金项目和面上项目函审专家,担任20多种国际专业杂志审稿专家。

研究方向:胶质细胞参与慢性疼痛调节的机制;痒觉和痛觉的神经环路;特殊环境下疼痛的传递和调制。

研究团队:本课题组有工作人员7名,其中教授2名、副研究员2名、副教授1名、助理研究员1名,实验师2名、研究生16名。课题组在研国家自然科学基金项目4项、青年基金项目1项、江苏省自然科学基金项目1项。

5年论文代表作(限10篇):

1. Zhi-Jun Zhang, Jian-Shuang Guo, Si-Si Li, Xiao-Bo Wu, De-Li Cao,Bao-Chun Jiang, Peng-Bo Jing, Xue-Qiang Bai, Chun-Hua Li, Zi-Han Wu1, Ying Lu,Yong-Jing Gao*. TLR8 and its endogenous ligand miR-21 contribute to neuropathic painin murine DRG.Journal of Experimental Medicine, 2018 Dec 3;215(12):3019-3037.

2.Bao-Chun Jiang, Wen-Wen Zhang, Tian Yang, Chang-Yun Guo, De-Li Cao,Zhi-Jun Zhang,Yong-Jing Gao*. Demethylation of G protein-coupled receptor 151 promoterfacilitates the binding of Kruppel-like factor 5 and enhances neuropathic painafter nerve injury inmice. Journal of Neuroscience,2018 Dec5;38(49):10535-10551.

3. Xiao-Bo Wu, Peng-Bo Jing, Zhi-Jun Zhang, De-Li Cao, Ming-Hui Gao,Bao-Chun Jiang,Yong-Jing Gao*.Chemokine receptor CCR2 contributes to neuropathicpain and the associated depression via increasing NR2B-mediated currents inboth D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleusaccumbens shell.Neuropsychopharmacology, 2018 Oct;43(11):2320-2330.

4. Bao-Chun Jiang, Li-Na He, Xiao-Bo Wu, Hui Shi, Wen-Wen Zhang, Zhi-JunZhang, De-Li Cao, Chun-Hua Li, Jun Gu,Yong-JingGao*. Promoted interaction of C/EBPa with demethylated Cxcr3 gene promoter contributesto neuropathic pain in mice.Journal of Neuroscience. 2017 Jan18;37(3):685-700.

5. Zhi-Jun Zhang ZJ, Bao-Chun Jiang,Yong-JingGao*. Chemokines in neuron-glial cell interaction and pathogenesis ofneuropathic pain.Cellular Molecular Life Science, 2017 Sep;74(18):3275-3291.

6. Bao-Chun Jiang, De-Li Cao, Xin Zhang, Zhi-Jun Zhang, Li-Na He, Chun-HuaLi, Wen-Wen Zhang, Xiao-Bo Wu, Temugin Berta, Ru-Rong Ji,Yong-Jing Gao*. CXCL13 drives spinal astrocyte activation andneuropathic pain via CXCR5.Journal of Clinical Investigation,2016 Feb 1;126(2):745-761.

7. Qian Zhang, De-Li Cao, Zhi-Jun Zhang, Bao-Chun Jiang,Yong-Jing Gao*. Chemokine CXCL13mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminalganglion of mice.J Neuroinflammation. 2016 Jul 11;13(1):183.

8. Yan Shen, Zhi-Jun Zhang,Ming-Di Zhu,Bao-Chun Jiang, Tian Yang,Yong-Jing Gao*. Exogenous induction ofHO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glialactivation in mice.Neurobiology of Disease. 2015 Jul;79:100-10.

9. Ying Lu, De-Li Cao, Bao-Chun Jiang, Tian Yang,Yong-Jing Gao*. MicroRNA-146a-5p attenuates neuropathic pain viasuppressing TRAF6 signaling in the spinal cord.Brain, Behavior, and Immunity.2015Oct;49:119-29.

10. Ying Lu, Bao-Chun Jiang, De-Li Cao, Zhi-Jun Zhang, Xin Zhang, Ru-RongJi,Yong-Jing Gao*. TRAF6upregulation in spinal astrocytes maintains neuropathic pain by integratingTNF-a and IL-1b signaling.Pain. 2014 Dec;155(12):2618-29.